ORMC Progressive Care Unit (PCU) Practice Test

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Which drug class includes losartan and provides RAAS blockade with vasodilation?

ACE inhibitors

ARBs

Losartan is an angiotensin II receptor blocker (ARB). ARBs block the angiotensin II type 1 receptor, so angiotensin II can’t cause vasoconstriction or stimulate aldosterone release. That leads to vasodilation and less sodium‑water retention, providing RAAS blockade with vasodilation. ACE inhibitors also block RAAS but do so by preventing formation of angiotensin II, whereas losartan acts at the receptor. The other classes don’t produce this RAAS blockade with vasodilation.

Beta blockers

Digoxin

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